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pentobarbital will decrease the extent or result of nisoldipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lessen the extent or outcome of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.Caution when discontinuing CYP3A4 inducers which are co